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Progressive Supranuclear Palsy

Corticobasal Degeneration (CBD) and progressive supranuclear palsy (PSP) are Parkinson's-plus syndromes, meaning that they are diseases that share some of the symptoms of Parkinson's Disease, such as slowing of movements, stiffness, tremors, falls, and shuffling of the feet. They may both also cause changes in memory and thinking.

People with PSP also develop problems moving their eyes, called supranuclear palsy, a wide-eyed appearance, and difficulty swallowing. Unlike Parkinson's disease, people often fall backward instead of forward. They may also develop severe stiffness in the neck.

There are several variations in the name of CBD, such as corticobasal syndrome or disease and corticobasal ganglionic degeneration. It is named after the damaged parts of the brain: the cortex (the outer part of the brain) and the basal ganglia (deep within the brain). Like Parkinson's disease, movement slowing, stiffness, tremors, falls, and shuffling of the feet are seen. Movement problems occur on one side of the body, such as stiffness, shaking, or loss of control. People with CBD may be unable to get their arms to do what they want, even if they know how. Sometimes, the arm on that side might move independently, which is called alien limb syndrome.

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